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OZONE THERAPY FOR ANIMALS

Ozone therapy has become a frequently used treatment method in animals as well as humans. It can be used to directly treat diseases or as a supportive treatment during the healing process. After ozone enters the body, it passes into the plasma and causes functional changes by targeting tissues such as erythrocytes, leukocytes, endothelium, and bone marrow. These changes are functional and include increasing oxygen transport, strengthening the immune system, releasing growth factors, increasing antioxidant enzymes, and forming of stem cells and erythrocytes. 

 “I love people who make me laugh. I honestly think it’s the thing I like most, to laugh. It cures a multitude of ills.” – Audrey Hepburn

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WHAT IS PROLOZONE THERAPY?

Prolozone therapy is a revolutionary technique used to treat damaged ligaments in a joint. Prolozone therapy falls within the category of regenerative medicine which is an injection administered by infusing the joint and surrounding tissues with collagen-producing materials and ozone gas to stimulate natural healing.

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This fascinating nonsurgical treatment for painful or injured ligaments works well for a variety of injuries.

Nonsurgical Repair of Damaged Ligaments

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This special kind of pain-relief injection therapy harnesses substances which foster the body’s production of collagen. These substances are combined with ozone gas, which works with the body to reconstruct damaged or injured ligament tissue.

The purpose is to completely heal the ligament, thereby relieving the patient of any further pain or disability. Prolozone can help to treat and repair the following conditions:

  • Chronic neck pain

  • Back pain

  • Hip arthritis/pain

  • Stifle(knee) injuries such as ACL and meniscal injuries

  • Shoulder pain

  • Elbow pain

  • Degenerative discs in the spine

  • Tendonitis

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How Prolozone Therapy Works

The word “prolozone” is a combination of “proliferation” and “ozone.” The holistic treatment enables the body to self-correct injury by fostering the healing of cells in and around the injured joint. It encourages the cells to proliferate and regrow.

 

Prolozone therapy can be used by veterinarians who treat patients with a wide range of acute and chronic musculoskeletal conditions. Prolozone is effective at addressing pain, as it assists in regenerating damaged ligaments – and once the ligament is fully healed, the pain will be gone for good however, Prolozone injections may need to be given periodically in some patients.

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Osteoarthritis wears away cartilage which provides a protective cushion between bones in a joint. When cartilage is worn away or worn down, bone-on-bone scraping is the painful result. Prolozone therapy may help restore the joint and relieve pain.

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Regenerative Medicine Therapy

Following prolozone therapy,  you may expect your pet to experience joint pain however, it should gradually decrease – and to hopefully go away completely.  Pre- and post-treatment X-rays have shown knee joints developed an increase in the thickness of collagen following the prolozone treatment.

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Prolozone therapy is nearly risk-free. A very small number of patients who have been treated with prolozone therapy have experienced an allergic reaction or pain at the injection site, but otherwise, patients report no ill side effects.

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If your pet suffers from chronic pain or lack of mobility in one or more joints, prolozone therapy may be the right choice to address their joint pain.

Ozonated Glycerin: A Targeted, Versatile Solution in Veterinary Care

Ozonated Glycerin

Ozonated glycerin is a potent and adaptable therapy in veterinary integrative medicine, offering sustained antimicrobial, anti-inflammatory, and immune-modulating benefits. As a stable, water-compatible carrier of medical ozone, it allows for safe, localized ozone delivery without the volatility of gas or the heaviness of oils. Ozonated glycerin has demonstrated effectiveness in both topical and injectable applications, supporting the treatment of localized infections, chronic inflammation, and immune-related disorders. In equine medicine, it is used as a supportive therapy for neurologic diseases such as Equine Protozoal Myeloencephalitis (EPM), reducing inflammation and supporting neural recovery. In companion animals, ozonated glycerin is applied topically, or administered intralesionally, intraperitoneally, subcutaneously, or intravenously to assist in cancer care, wound healing, and systemic recovery. Its mucosal compatibility makes it particularly useful in dental, ophthalmic, and otic applications. Additionally, exotic species—including birds, reptiles, and small mammals—can benefit from the gentle, non-irritating properties of ozonated glycerin in managing infections, wounds, and inflammatory conditions.

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Whether used as a topical, joint-adjacent, or injectable agent, ozonated glycerin provides a safe and effective method to harness ozone’s healing properties across a wide range of veterinary patients—without invasive procedures.

 

Important Note: Ozonated glycerin should only be administered by a licensed veterinarian specifically trained in medical ozone therapy. Proper technique, dosing, and safety are essential for therapeutic success. At this time, ozonated glycerin is considered an experimental modality and is used for research and investigational purposes only.

 

Regeno3one Vet offers a detailed, 60-page protocol guide available for purchase, outlining exact uses, dosing, and species-specific techniques to help trained professionals confidently incorporate ozonated glycerin into their veterinary practice.

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Conditions Treated with Ozonated Glycerin (OG)

Diseases and conditions ozonated glycerin (OG) may be used to support or treat in veterinary medicine, organized by body system/application area:

 

Dermatologic / Wound Care:

  • Chronic non-healing wounds

  • Surgical site support

  • Hot spots and pyoderma

  • Burns and abscesses

  • Bacterial and fungal skin infections

Dental / Oral Health:

  • Gingivitis and stomatitis

  • Periodontal disease

  • Oral ulcers and dental abscesses

  • Post-extraction healing support

Ophthalmic:

  • Conjunctivitis (bacterial/viral)

  • Corneal ulcers

  • Periocular inflammation/infection

Cancer Support:

  • Intratumoral or peritumoral injections (e.g., mammary tumors, sarcomas)

  • Local immune stimulation

  • Intraperitoneal and Intravenous applications

  • Tumor oxygenation and inflammation reduction

Neurologic / Musculoskeletal:

  • Equine Protozoal Myeloencephalitis (EPM) support

  • Joint pain and periarticular inflammation

  • Myofascial trigger points and chronic stiffness

Infectious / Systemic Disease:

  • Draining tracts and fistulas

  • Otitis externa (when combined with ozone oil flushes)

  • Local support in cases of resistant bacterial infections

  • Support in viral outbreaks (e.g., papilloma virus, herpes)

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