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Ozone therapy has become a frequently used treatment method in animals as well as humans. It can be used to directly treat diseases or as a supportive treatment during the healing process. After ozone enters the body, it passes into the plasma and causes functional changes by targeting tissues such as erythrocytes, leukocytes, endothelium, and bone marrow. These changes are functional and include increasing oxygen transport, strengthening the immune system, releasing growth factors, increasing antioxidant enzymes, and forming of stem cells and erythrocytes. 

 “I love people who make me laugh. I honestly think it’s the thing I like most, to laugh. It cures a multitude of ills.” – Audrey Hepburn



Prolozone therapy is a revolutionary technique used to treat damaged ligaments in a joint. Prolozone therapy falls within the category of regenerative medicine which is an injection administered by infusing the joint and surrounding tissues with collagen-producing materials and ozone gas to stimulate natural healing.

This fascinating nonsurgical treatment for painful or injured ligaments works well for a variety of injuries.

Nonsurgical Repair of Damaged Ligaments

This special kind of pain-relief injection therapy harnesses substances which foster the body’s production of collagen. These substances are combined with ozone gas, which works with the body to reconstruct damaged or injured ligament tissue.

The purpose is to completely heal the ligament, thereby relieving the patient of any further pain or disability. Prolozone can help to treat and repair the following conditions:

  • Chronic neck pain

  • Back pain

  • Hip arthritis/pain

  • Stifle(knee) injuries such as ACL and meniscal injuries

  • Shoulder pain

  • Elbow pain

  • Degenerative discs in the spine

  • Tendonitis

How Prolozone Therapy Works

The word “prolozone” is a combination of “proliferation” and “ozone.” The holistic treatment enables the body to self-correct injury by fostering the healing of cells in and around the injured joint. It encourages the cells to proliferate and regrow.


Prolozone therapy can be used by veterinarians who treat patients with a wide range of acute and chronic musculoskeletal conditions. Prolozone is effective at addressing pain, as it assists in regenerating damaged ligaments – and once the ligament is fully healed, the pain will be gone for good however, Prolozone injections may need to be given periodically in some patients.

Osteoarthritis wears away cartilage which provides a protective cushion between bones in a joint. When cartilage is worn away or worn down, bone-on-bone scraping is the painful result. Prolozone therapy may help restore the joint and relieve pain.

Regenerative Medicine Therapy

Following prolozone therapy,  you may expect your pet to experience joint pain however, it should gradually decrease – and to hopefully go away completely.  Pre- and post-treatment X-rays have shown knee joints developed an increase in the thickness of collagen following the prolozone treatment.

Prolozone therapy is nearly risk-free. A very small number of patients who have been treated with prolozone therapy have experienced an allergic reaction or pain at the injection site, but otherwise, patients report no ill side effects.

If your pet suffers from chronic pain or lack of mobility in one or more joints, prolozone therapy may be the right choice to address their joint pain.

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